In 2016 the Chicago Council Survey of public opinion recorded its highest levels of support for globalization. Yet anti-globalist sentiments have often set the tone during the presidential election campaign. Candidates of all stripes have accused free trade of eliminating jobs and depressing wages, while immigrants and international organizations have come under frequent fire. Internationally too, the Brexit vote was a landmark rejection of economic and political integration by UK voters. How should we think about the global challenges facing the next administration? How should they take account of skepticism around the world regarding open markets and also serve America’s vital interests in an increasingly interdependent world?