Tel Aviv and Berlin recently ranked as the world’s most LGBTQI+ friendly cities based on legal protection and social acceptance. And a new survey placed London as the most women-friendly city, where women were leading in public service, the arts, politics, science, and business. While some global cities are addressing disparity through inclusive policy and design efforts, structures of inequality affecting women and LGBTQI+ persons continue to exist. Across countless cities these groups are disproportionately excluded from many spheres of society, including access to basic services, equal participation in leadership, governance and city planning. What policies and urban planning decisions do global cities need to embrace in order to become more inclusive, livable, and prosperous? How can global cities like Chicago create safe and open spaces for different social groups to gather and engage in open dialogue and freedom of expression?